hydrogel of poloxamer for wound management. The formation of CPC leads to

physical state conversion of curcumin from crystalline to amorphous which

improves its transdermal release efficacy from the in situ forming hydrogel as

compared to release of pure curcumin from in situ forming hydrogel. Further,

in vitro release study shows a very sustained and controlled release kinetics for

CPC, while a burst release is evident for pure curcumin (Du et al. 2016). The

Tecomella undulata is well-known for its antibacterial property. The step bark of

Tecomella undulata comprises tecomin which is widely used in wound management

since ancient time (Ullah et al. 2008). The incorporation of 7.5 wt% (with respect to

polymer) of tecomin into PCL/PVP nanofibre through electrospinning technique

improves the stability of the herbal drug and increases fibre diameter and pore size in

the nanofibre mat. In vitro release study exhibits a burst release of the herbal drug

initially (almost 24% in 4 h) and followed by a control release of drug ~40% in 24 h

which corresponds to a cumulative release of ~3.5 wt% (with respect to polymer) of

the drug from the dressing mat (Suganya et al. 2011). The zone of inhibition study

has been carried out against the pathogenic bacteria P. aeruginosa MTCC 2297,

S. aureus ATCC 933 and E. coli (IP-406006), and pure PCL/PVP nanofibre is taken

as control. A considerable zone of inhibition with drug-loaded nanofibre mat

suggests superior antibacterial property of the drug-loaded electrospun mat. Zataria

multiflora nanoemulsion is well-known for its wound healing activity. A wound

Fig. 30.1 Characterization of wound dressing materials: (a) (i) the SEM investigation shows 3D

porous structure of composite hydrogel of PAP, CBM and carboxymethyl cellulose (CMC); (ii) the

swelling ratio of the composite hydrogel in presence of different amount of herbal drug (PAP); (b)

(i) cumulative release kinetics of the herbal drug from cellulose acetate/gelatine nanofibre revealing

more control release of the drug with increasing the gelatine content; (ii) the demonstration of

antibacterial activities of the electrospun nanofibres using zone of inhibition method (1).

CA/gel ¼ 100:0 with drug, (2) CA/gel ¼ 50:50 with drug, (3) CA/gel ¼ 100:0 without drug,

(4) CA/gel ¼ 50:50 without drug; and (c) fluorescent images of 3T3 fibroblast cells after staining

with AO/EB after 3 days of cell proliferation in presence of different dressing materials

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A. Biswas et al.